A Longitudinal Renal Health Outcome for Clinical Trials in Acute Kidney Injury?

I think so, but a first step could be what I did using SUPPORT data where you do landmark analyses where you keep restarting follow-up at later times, and use the SCr and other variables’ history up until the landmark to predict post-landmark outcomes. This gives you a prognostic scoring of the input variables you are trying summarize into a self-contained and powerful current status measure. You do have to have a suitable outcome to anchor the analysis, e.g., the union of death and dialysis. Or you could predict ultimate deterioration in function by predicting SCr or just urine output as your anchor outcome.