Where are the exceptional responders?
Datamethods Discussion Forum [Unofficial]
April 16, 2026
the Guardian – 16 Apr 26
Effect of ‘gamechanger’ Alzheimer’s drugs ‘trivial’, review concludes
Data assessed from 17 clinical trials of anti-amyloid drugs found no ‘meaningful effect’ on cognitive decline
This Cochrane analysis is criticized by several experts interviewed for the article, for pooling many different drugs. The marginality analysis I’ve advocated, by contrast, can be directed pointedly against an individual drug.
Discussion in the ATmosphere