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  "path": "/t/where-are-the-exceptional-responders/17961#post_12",
  "publishedAt": "2026-04-16T10:08:08.000Z",
  "site": "https://discourse.datamethods.org",
  "tags": [
    "the Guardian – 16 Apr 26",
    "Effect of ‘gamechanger’ Alzheimer’s drugs ‘trivial’, review concludes",
    "This Cochrane analysis"
  ],
  "textContent": "the Guardian – 16 Apr 26\n\n### Effect of ‘gamechanger’ Alzheimer’s drugs ‘trivial’, review concludes\n\nData assessed from 17 clinical trials of anti-amyloid drugs found no ‘meaningful effect’ on cognitive decline\n\nThis Cochrane analysis is criticized by several experts interviewed for the article, for pooling many different drugs. The _marginality_ analysis I’ve advocated, by contrast, can be directed pointedly against an individual drug.",
  "title": "Where are the exceptional responders?"
}