Decision Analysis in Clinical Guidelines: Net Benefit, NNT, & NRI
Datamethods Discussion Forum [Unofficial]
March 31, 2026
As I understand it (have not thought much about NNT), if ARR is absolute risk reduction,
NNT = 1/ARR = 1 / (P(ASCVD|Tx)-P(ASCVD|No Tx))
The graph claims, if P(ASCVD) = 3%, NNT=100? I am assuming it’s P(ASCVD) on the x-axis, because that is what the pooled cohort equations (2013) and Prevent calculate, for example.
But NNT does not depend on P(ASCVD), it depends on P(ASCVD|Tx), P(ASCVD|No Tx)…
How to then get NNT from P(ASCVD) alone?
Also they say RRR = 35%; RRR I think is P(ASCVD|Tx)/P(ASCVD|No Tx)?
What’s NND stand for?
Discussion in the ATmosphere