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Decision Analysis in Clinical Guidelines: Net Benefit, NNT, & NRI

Datamethods Discussion Forum [Unofficial] March 31, 2026
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As I understand it (have not thought much about NNT), if ARR is absolute risk reduction, NNT = 1/ARR = 1 / (P(ASCVD|Tx)-P(ASCVD|No Tx)) The graph claims, if P(ASCVD) = 3%, NNT=100? I am assuming it’s P(ASCVD) on the x-axis, because that is what the pooled cohort equations (2013) and Prevent calculate, for example. But NNT does not depend on P(ASCVD), it depends on P(ASCVD|Tx), P(ASCVD|No Tx)… How to then get NNT from P(ASCVD) alone? Also they say RRR = 35%; RRR I think is P(ASCVD|Tx)/P(ASCVD|No Tx)? What’s NND stand for?

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