{
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  "path": "/t/decision-analysis-in-clinical-guidelines-net-benefit-nnt-nri/28682#post_2",
  "publishedAt": "2026-03-31T01:21:26.000Z",
  "site": "https://discourse.datamethods.org",
  "textContent": "As I understand it (have not thought much about NNT), if ARR is absolute risk reduction,\n\nNNT = 1/ARR = 1 / (P(ASCVD|Tx)-P(ASCVD|No Tx))\n\nThe graph claims, if P(ASCVD) = 3%, NNT=100? I am assuming it’s P(ASCVD) on the x-axis, because that is what the pooled cohort equations (2013) and Prevent calculate, for example.\n\nBut NNT does not depend on P(ASCVD), it depends on P(ASCVD|Tx), P(ASCVD|No Tx)…\n\nHow to then get NNT from P(ASCVD) alone?\n\nAlso they say RRR = 35%; RRR I think is P(ASCVD|Tx)/P(ASCVD|No Tx)?\n\nWhat’s NND stand for?",
  "title": "Decision Analysis in Clinical Guidelines: Net Benefit, NNT, & NRI"
}