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Every Potion in Slay the Spire 2 and What It Does

All Things How March 10, 2026

Slay the Spire 2 entered early access on March 5, 2026, and it brought a massive expansion to the potion system. The roster has grown from the original game's roughly 40 potions to 63, spread across the Ironclad, Silent, Defect, and two brand-new characters — the Necrobinder and the Regent — plus a large pool of Colorless potions available to everyone. Potions remain single-use consumables that cost no Energy and don't count as playing a card, making them powerful tempo tools for swinging elite and boss fights in your favor.

Quick answer: Slay the Spire 2 has 63 potions in its early access build, categorized by rarity (Common, Uncommon, Rare, Event, and Token) and by character affinity. Many returning favorites have been reworked, and over two dozen potions are entirely new.

Slay the Spire 2 has 63 potions in its early access build | Image credit: Mega Crit (via YouTube/@Friendly Frenzy Games)

Colorless Common Potions

Colorless potions can appear for any character. The Common tier is the most frequently dropped, making these the potions you'll encounter most often across runs.

Potion	Effect
Attack Potion	Choose 1 of 3 random Attack cards to add to your Hand. It's free to play this turn.
Block Potion	Gain 12 Block.
Colorless Potion	Choose 1 of 3 random Colorless cards to add to your Hand. It's free to play this turn.
Dexterity Potion	Gain 2 Dexterity.
Energy Potion	Gain 2 Energy.
Explosive Ampoule	Deal 10 damage to ALL enemies.
Fire Potion	Deal 20 damage.
Flex Potion	Gain 5 Strength. At the end of your turn, lose 5 Strength.
Power Potion	Choose 1 of 3 random Power cards to add to your Hand. It's free to play this turn.
Skill Potion	Choose 1 of 3 random Skill cards to add to your Hand. It's free to play this turn.
Speed Potion	Gain 5 Dexterity. At the end of your turn, lose 5 Dexterity.
Strength Potion	Gain 2 Strength.
Swift Potion	Draw 3 cards.
Vulnerable Potion	Apply 3 Vulnerable.
Weak Potion	Apply 3 Weak.

Note that the old Explosive Potion has been renamed to Explosive Ampoule, and the Fear Potion has been replaced by the Vulnerable Potion, though the effect of applying Vulnerable remains similar.

Colorless potions can appear for any character | Image credit: Mega Crit (via YouTube/@Friendly Frenzy Games)

Colorless Uncommon Potions

Uncommon potions show up less frequently but tend to offer more impactful or specialized effects. Several of these are brand new to the sequel.

Potion	Effect
Blessing of the Forge	Upgrade all cards in your Hand for the rest of combat.
Clarity Extract	Draw 1 card. At the start of your next 3 turns, draw 1 additional card.
Cure All	Gain 1 Energy. Draw 2 cards.
Duplicator	This turn, your next card is played an extra time.
Fortifier	Triple your Block.
Fysh Oil	Gain 1 Strength and 1 Dexterity.
Gambler's Brew	Discard any number of cards, then draw that many.
Heart of Iron	Gain 7 Plating.
Liquid Bronze	Gain 3 Thorns.
Potion of Binding	Apply 1 Weak and 1 Vulnerable to ALL enemies.
Powdered Demise	Enemy loses 9 HP at the end of each of its turns.
Radiant Tincture	Gain 1 Energy. Gain an additional Energy at the start of your next 3 turns.
Regen Potion	Gain 5 Regen.
Stable Serum	Retain your Hand for 2 turns.
Touch of Insanity	Choose a card in your Hand. It is free to play this combat.

Fortifier is a standout newcomer — tripling your existing Block can be devastating when paired with a big defensive turn. Powdered Demise and Radiant Tincture are also entirely new and offer sustained value over multiple turns rather than a single burst.

Uncommon potions show up less frequently but tend to offer more impactful or specialized effects | Image credit: Mega Crit (via YouTube/@Friendly Frenzy Games)

Colorless Rare Potions

Rare potions are the hardest to find naturally but deliver the most dramatic effects. Several returning favorites sit alongside powerful new additions.

Potion	Effect
Beetle Juice	Enemy's attacks deal 30% less damage for the next 4 turns.
Bottled Potential	Shuffle ALL your cards into your Draw Pile. Draw 5 cards.
Distilled Chaos	Play the top 3 cards of your Draw Pile.
Droplet of Precognition	Choose a card in your Draw Pile and add it to your Hand.
Entropic Brew	Fill all your empty potion slots with random potions.
Fairy in a Bottle	When you would die, this potion is discarded and you heal to 30% of your Max HP.
Fruit Juice	Gain 5 Max HP.
Gigantification Potion	The next Attack you play deals triple damage.
Liquid Memories	Put a card from your Discard Pile into your Hand. It costs 0 Energy this turn.
Lucky Tonic	Gain 1 Ritual.
Mazaleth's Gift	Add a random Attack, Skill, and Power into your Hand. They're free to play this turn.
Orobic Acid	Exhaust your Hand. Draw 10 cards.
Shackling Potion	ALL enemies lose 7 Strength this turn.
Ship in a Bottle	Gain 10 Block. Next turn, gain 10 Block.
Snecko Oil	Draw 7 cards. Randomize the cost of cards in your Hand this turn.

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Gigantification Potion is new and extremely powerful — tripling your next Attack's damage can one-shot many elites when combined with high-cost cards like Bludgeon or Skewer.

Several potions have shifted rarity compared to the first game. Blessing of the Forge moved from Common to Uncommon, Distilled Chaos jumped from Uncommon to Rare, and Heart of Iron dropped from Rare to Uncommon with adjusted values (7 Plating instead of 6 Metallicize). Liquid Memories also climbed from Uncommon to Rare.

Rare potions are the hardest to find naturally but deliver the most dramatic effects | Image credit: Mega Crit (via YouTube/@Friendly Frenzy Games)

Character-Exclusive Potions

Each of the five playable characters has a small set of potions that only appear during their runs. The Necrobinder and Regent are new to Slay the Spire 2 and bring entirely fresh potion designs.

Ironclad

Potion	Rarity	Effect
Blood Potion	Common	Heal for 20% of your Max HP.
Ashwater	Uncommon	Exhaust any number of cards in your Hand.
Soldier's Stew	Rare	All cards containing Strike gain 1 Replay this combat.

Ashwater replaces the old Elixir with the same exhaust effect but under a new name. Soldier's Stew is brand new and tailor-made for Strike-heavy builds, granting permanent Replay to every Strike card for the rest of the fight.

Silent

Potion	Rarity	Effect
Poison Potion	Common	Apply 6 Poison.
Cunning Potion	Uncommon	Add 3 Upgraded Shivs into your Hand.
Ghost in a Jar	Rare	Gain 1 Intangible.

Defect

Potion	Rarity	Effect
Focus Potion	Common	Gain 2 Focus.
Potion of Capacity	Uncommon	Gain 2 Orb Slots.
Essence of Darkness	Rare	Channel a Dark for each of your Orb Slots.

Necrobinder

Potion	Rarity	Effect
Potion of Doom	Common	Apply 33 Doom.
Bone Brew	Uncommon	Summon 15.
Pot of Ghouls	Rare	Add 2 Souls into your Hand.

The Necrobinder's potions revolve around its unique mechanics: Doom is a devastating debuff, Summon fuels the character's minion-based gameplay, and Souls are special generated cards.

Regent

Potion	Rarity	Effect
Star Potion	Common	Gain 3 Star Energy.
King's Courage	Uncommon	Forge 15.
Cosmic Concoction	Rare	Add 3 Upgraded Colorless cards into your Hand.

The Regent uses Star Energy as its unique resource, and Forge is a character-specific mechanic. Cosmic Concoction is particularly flexible since it generates upgraded Colorless cards, giving access to a wide range of effects.

All five playable characters have a set of potions that only appear during their runs | Image credit: Mega Crit (via YouTube/@Friendly Frenzy Games)

Event and Token Potions

Two potions are tied to specific events, and one is classified as a Token, meaning it doesn't appear through normal drop mechanics.

Potion	Type	Effect
Foul Potion	Event	Deal 12 damage to EVERYONE. Can be thrown at the Merchant for 100 Gold instead.
Glowwater Potion	Event	Gain 1 Buffer.
Potion-Shaped Rock	Token	Deal 15 damage.

Foul Potion has a fun dual purpose — you can use it as AoE damage in combat or throw it at the Merchant to earn 100 Gold, which is a nice callback to the original game's quirky interactions. Glowwater Potion grants Buffer, which negates the next instance of HP loss entirely.

Key Changes From Slay the Spire 1

The sequel made several notable adjustments beyond simply adding new potions. Many returning potions have been rebalanced or reclassified. Blessing of the Forge is now Uncommon instead of Common. Snecko Oil draws 7 cards instead of 5 and only randomizes costs for the current turn rather than the rest of combat. Heart of Iron now grants Plating (a new buff) rather than Metallicize and sits at Uncommon rarity. The Watcher's exclusive potions (Bottled Miracle, Stance Potion, and Ambrosia) are absent since the Watcher is not in the early access roster.

Several potions that were previously character-locked have become Colorless or shifted ownership. The Ancient Potion and Essence of Steel from the first game don't appear in the current build, while entirely new entries like Beetle Juice, Fortifier, Gigantification Potion, and Stable Serum fill out the expanded roster. The game is still in early access, so expect these numbers and effects to shift as development continues.