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  "description": "The sequel's early access launched with 63 potions spanning six characters — here's the full breakdown.",
  "path": "/every-potion-in-slay-the-spire-2-and-what-it-does/",
  "publishedAt": "2026-03-10T04:04:14.000Z",
  "site": "https://allthings.how",
  "tags": [
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  "textContent": "Slay the Spire 2 entered early access on March 5, 2026, and it brought a massive expansion to the potion system. The roster has grown from the original game's roughly 40 potions to 63, spread across the Ironclad, Silent, Defect, and two brand-new characters — the Necrobinder and the Regent — plus a large pool of Colorless potions available to everyone. Potions remain single-use consumables that cost no Energy and don't count as playing a card, making them powerful tempo tools for swinging elite and boss fights in your favor.\n\n**Quick answer:** Slay the Spire 2 has 63 potions in its early access build, categorized by rarity (Common, Uncommon, Rare, Event, and Token) and by character affinity. Many returning favorites have been reworked, and over two dozen potions are entirely new.\n\nSlay the Spire 2 has 63 potions in its early access build | Image credit: __Mega Crit (via YouTube/@Friendly Frenzy Games)__\n\n* * *\n\n## Colorless Common Potions\n\nColorless potions can appear for any character. The Common tier is the most frequently dropped, making these the potions you'll encounter most often across runs.\n\nPotion| Effect\n---|---\nAttack Potion| Choose 1 of 3 random Attack cards to add to your Hand. It's free to play this turn.\nBlock Potion| Gain 12 Block.\nColorless Potion| Choose 1 of 3 random Colorless cards to add to your Hand. It's free to play this turn.\nDexterity Potion| Gain 2 Dexterity.\nEnergy Potion| Gain 2 Energy.\nExplosive Ampoule| Deal 10 damage to ALL enemies.\nFire Potion| Deal 20 damage.\nFlex Potion| Gain 5 Strength. At the end of your turn, lose 5 Strength.\nPower Potion| Choose 1 of 3 random Power cards to add to your Hand. It's free to play this turn.\nSkill Potion| Choose 1 of 3 random Skill cards to add to your Hand. It's free to play this turn.\nSpeed Potion| Gain 5 Dexterity. At the end of your turn, lose 5 Dexterity.\nStrength Potion| Gain 2 Strength.\nSwift Potion| Draw 3 cards.\nVulnerable Potion| Apply 3 Vulnerable.\nWeak Potion| Apply 3 Weak.\n\nNote that the old Explosive Potion has been renamed to Explosive Ampoule, and the Fear Potion has been replaced by the Vulnerable Potion, though the effect of applying Vulnerable remains similar.\n\nColorless potions can appear for any character | Image credit: __Mega Crit (via YouTube/@Friendly Frenzy Games)__\n\n* * *\n\n## Colorless Uncommon Potions\n\nUncommon potions show up less frequently but tend to offer more impactful or specialized effects. Several of these are brand new to the sequel.\n\nPotion| Effect\n---|---\nBlessing of the Forge| Upgrade all cards in your Hand for the rest of combat.\nClarity Extract| Draw 1 card. At the start of your next 3 turns, draw 1 additional card.\nCure All| Gain 1 Energy. Draw 2 cards.\nDuplicator| This turn, your next card is played an extra time.\nFortifier| Triple your Block.\nFysh Oil| Gain 1 Strength and 1 Dexterity.\nGambler's Brew| Discard any number of cards, then draw that many.\nHeart of Iron| Gain 7 Plating.\nLiquid Bronze| Gain 3 Thorns.\nPotion of Binding| Apply 1 Weak and 1 Vulnerable to ALL enemies.\nPowdered Demise| Enemy loses 9 HP at the end of each of its turns.\nRadiant Tincture| Gain 1 Energy. Gain an additional Energy at the start of your next 3 turns.\nRegen Potion| Gain 5 Regen.\nStable Serum| Retain your Hand for 2 turns.\nTouch of Insanity| Choose a card in your Hand. It is free to play this combat.\n\nFortifier is a standout newcomer — tripling your existing Block can be devastating when paired with a big defensive turn. Powdered Demise and Radiant Tincture are also entirely new and offer sustained value over multiple turns rather than a single burst.\n\nUncommon potions show up less frequently but tend to offer more impactful or specialized effects | Image credit: __Mega Crit (via YouTube/@Friendly Frenzy Games)__\n\n* * *\n\n## Colorless Rare Potions\n\nRare potions are the hardest to find naturally but deliver the most dramatic effects. Several returning favorites sit alongside powerful new additions.\n\nPotion| Effect\n---|---\nBeetle Juice| Enemy's attacks deal 30% less damage for the next 4 turns.\nBottled Potential| Shuffle ALL your cards into your Draw Pile. Draw 5 cards.\nDistilled Chaos| Play the top 3 cards of your Draw Pile.\nDroplet of Precognition| Choose a card in your Draw Pile and add it to your Hand.\nEntropic Brew| Fill all your empty potion slots with random potions.\nFairy in a Bottle| When you would die, this potion is discarded and you heal to 30% of your Max HP.\nFruit Juice| Gain 5 Max HP.\nGigantification Potion| The next Attack you play deals triple damage.\nLiquid Memories| Put a card from your Discard Pile into your Hand. It costs 0 Energy this turn.\nLucky Tonic| Gain 1 Ritual.\nMazaleth's Gift| Add a random Attack, Skill, and Power into your Hand. They're free to play this turn.\nOrobic Acid| Exhaust your Hand. Draw 10 cards.\nShackling Potion| ALL enemies lose 7 Strength this turn.\nShip in a Bottle| Gain 10 Block. Next turn, gain 10 Block.\nSnecko Oil| Draw 7 cards. Randomize the cost of cards in your Hand this turn.\n\n⚡\n\nGigantification Potion is new and extremely powerful — tripling your next Attack's damage can one-shot many elites when combined with high-cost cards like Bludgeon or Skewer.\n\nSeveral potions have shifted rarity compared to the first game. Blessing of the Forge moved from Common to Uncommon, Distilled Chaos jumped from Uncommon to Rare, and Heart of Iron dropped from Rare to Uncommon with adjusted values (7 Plating instead of 6 Metallicize). Liquid Memories also climbed from Uncommon to Rare.\n\nRare potions are the hardest to find naturally but deliver the most dramatic effects | Image credit: __Mega Crit (via YouTube/@Friendly Frenzy Games)__\n\n* * *\n\n## Character-Exclusive Potions\n\nEach of the five playable characters has a small set of potions that only appear during their runs. The Necrobinder and Regent are new to Slay the Spire 2 and bring entirely fresh potion designs.\n\n### Ironclad\n\nPotion| Rarity| Effect\n---|---|---\nBlood Potion| Common| Heal for 20% of your Max HP.\nAshwater| Uncommon| Exhaust any number of cards in your Hand.\nSoldier's Stew| Rare| All cards containing Strike gain 1 Replay this combat.\n\nAshwater replaces the old Elixir with the same exhaust effect but under a new name. Soldier's Stew is brand new and tailor-made for Strike-heavy builds, granting permanent Replay to every Strike card for the rest of the fight.\n\n### Silent\n\nPotion| Rarity| Effect\n---|---|---\nPoison Potion| Common| Apply 6 Poison.\nCunning Potion| Uncommon| Add 3 Upgraded Shivs into your Hand.\nGhost in a Jar| Rare| Gain 1 Intangible.\n\n### Defect\n\nPotion| Rarity| Effect\n---|---|---\nFocus Potion| Common| Gain 2 Focus.\nPotion of Capacity| Uncommon| Gain 2 Orb Slots.\nEssence of Darkness| Rare| Channel a Dark for each of your Orb Slots.\n\n### Necrobinder\n\nPotion| Rarity| Effect\n---|---|---\nPotion of Doom| Common| Apply 33 Doom.\nBone Brew| Uncommon| Summon 15.\nPot of Ghouls| Rare| Add 2 Souls into your Hand.\n\nThe Necrobinder's potions revolve around its unique mechanics: Doom is a devastating debuff, Summon fuels the character's minion-based gameplay, and Souls are special generated cards.\n\n### Regent\n\nPotion| Rarity| Effect\n---|---|---\nStar Potion| Common| Gain 3 Star Energy.\nKing's Courage| Uncommon| Forge 15.\nCosmic Concoction| Rare| Add 3 Upgraded Colorless cards into your Hand.\n\nThe Regent uses Star Energy as its unique resource, and Forge is a character-specific mechanic. Cosmic Concoction is particularly flexible since it generates upgraded Colorless cards, giving access to a wide range of effects.\n\nAll five playable characters have a set of potions that only appear during their runs | Image credit: __Mega Crit (via YouTube/@Friendly Frenzy Games)__\n\n* * *\n\n## Event and Token Potions\n\nTwo potions are tied to specific events, and one is classified as a Token, meaning it doesn't appear through normal drop mechanics.\n\nPotion| Type| Effect\n---|---|---\nFoul Potion| Event| Deal 12 damage to EVERYONE. Can be thrown at the Merchant for 100 Gold instead.\nGlowwater Potion| Event| Gain 1 Buffer.\nPotion-Shaped Rock| Token| Deal 15 damage.\n\nFoul Potion has a fun dual purpose — you can use it as AoE damage in combat or throw it at the Merchant to earn 100 Gold, which is a nice callback to the original game's quirky interactions. Glowwater Potion grants Buffer, which negates the next instance of HP loss entirely.\n\n* * *\n\n## Key Changes From Slay the Spire 1\n\nThe sequel made several notable adjustments beyond simply adding new potions. Many returning potions have been rebalanced or reclassified. Blessing of the Forge is now Uncommon instead of Common. Snecko Oil draws 7 cards instead of 5 and only randomizes costs for the current turn rather than the rest of combat. Heart of Iron now grants Plating (a new buff) rather than Metallicize and sits at Uncommon rarity. The Watcher's exclusive potions (Bottled Miracle, Stance Potion, and Ambrosia) are absent since the Watcher is not in the early access roster.\n\nSeveral potions that were previously character-locked have become Colorless or shifted ownership. The Ancient Potion and Essence of Steel from the first game don't appear in the current build, while entirely new entries like Beetle Juice, Fortifier, Gigantification Potion, and Stable Serum fill out the expanded roster. The game is still in early access, so expect these numbers and effects to shift as development continues.",
  "title": "Every Potion in Slay the Spire 2 and What It Does",
  "updatedAt": "2026-03-10T04:04:16.020Z"
}