Thirty years later: A reappraisal of Alzheimer's disease risk in Japanese APOE-e4 homozygotes

Researchers at Niigata University have conducted the first comprehensive reappraisal in nearly 30 years of the risk of Alzheimer's disease (AD) associated with APOE-e4 homozygosity (e4*4) in the Japanese population. Their findings, published in the journal Molecular Neurodegeneration, suggest that the risk, while still substantial, is lower than estimates that have been widely cited since the 1990s.