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  "path": "/news/2026-06-years-reappraisal-alzheimer-disease-japanese.html",
  "publishedAt": "2026-06-29T09:00:01.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "Researchers at Niigata University have conducted the first comprehensive reappraisal in nearly 30 years of the risk of Alzheimer's disease (AD) associated with APOE-e4 homozygosity (e4*4) in the Japanese population. Their findings, published in the journal Molecular Neurodegeneration, suggest that the risk, while still substantial, is lower than estimates that have been widely cited since the 1990s.",
  "title": "Thirty years later: A reappraisal of Alzheimer's disease risk in Japanese APOE-e4 homozygotes"
}