Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases

In autoimmune disorders, immune cells targeting "self" proteins are mistakenly activated, resulting in abnormal expansion and responsiveness. These disorders are known to reduce patients' quality of life over a prolonged period. This can be attributed to CD4+ T cells, which play a key role in inducing persistent inflammation, recruiting other immune cells, including antibody-producing B cells, and inflicting tissue damage.