Future cancer therapy could use immunity to clean up damaged DNA by modulating AUF1

Researchers have identified a pathway that triggers an immune response in cells with defective DNA repair. In particular, the authors of a new paper demonstrated how the downregulation of AUF1 impairs DNA repair, followed by activation of the immune response due to the presence of R-loops in the cytoplasm. This represents an important finding for the development of new therapeutic strategies aimed at modulating the immune response upon DNA damage.