Method for operating an internal combustion engine with a turbocharger arrangement and control unit for an engine with a turbocharger arrangement

In a method for operating an internal combustion engine (1) with a turbocharger arrangement (2) comprising a low-pressure and a high-pressure stage arranged sequentially, the low-pressure stage comprising a low-pressure compressor (9), and at least one turbocharger control valve (15, 16) operable by a supply system, a supply system failure is detected, a low-pressure compressor flow is determined, and an engine control parameter setpoint is limited depending on the low-pressure compressor flow. The invention also relates to a control unit for an internal combustion engine (1).