Method for operating an assistance system of an at least temporarily autonomously operable vehicle

An assistance system influences an asleep and/or awake state of a vehicle occupant to at least temporarily take over a vehicle guidance function by detecting the asleep and/or awake state of the vehicle occupant using a detection device to generate takeover capability information, detecting, receiving, and/or generating destination arrival information, at least temporarily influencing the asleep and/or awake state of the vehicle occupant by an influencing device, such that there is a defined minimum takeover capability of the vehicle occupant to take over a vehicle guidance function for the vehicle occupant for at least a portion of the journey and/or travel time at least over a portion of the journey and/or travel time.