Engine block and internal combustion engine with an engine block

An engine block (10, 110) for an internal combustion engine (1, 100) with a two-stage turbocharged system (12, 112) may comprise a top side (21), a first end side (18L), and a second end side (18H), the second end side (18H) opposing the first end side (18H), and a compressor connection (34) is formed within the engine block (10, 110), the compressor connection (34) having a low-pressure side opening (50L) at the first end side (18L) for having charge air entered and a high-pressure side opening (50H) at the second end side (18H) for having charge air discharged.