Seal and seal assembly for a motor vehicle, in particular for sealing a bodywork

The seal (10) has a sealing section (20) and a fastening section (30) including a supporting section that is supported in a supporting region of a flange (120). A fixing section (32) is fixed to a fixing region of the flange, where the supporting section and the fixing section are arranged behind each other along longitudinal direction. The fixing region includes an opening that is formed by inner and outer frame parts (123, 124), and the supporting section and the fixing section are separated from each other along the longitudinal direction by an intermediate chamber.