Mixing animations with Ragdoll behaviour

I am trying to create a character that is animated - for now using Mixamo animations - but also behaves like a ragdoll when hit by a ball. And I am struggling with how to set this up. Is there a way to leave this entirely to Minie physics DAC? Or should I detect the moment of impact and turn the character into a ragdoll? I want the character to either fall down completely or recover and continue it’s plan. And eventually I also want the body to respond to movements and acceleration. I also plan to combine animations, like the legs walking and one arm point to a location. The rest of the body should respond like a ragdoll. What would be the best setup to get this flexibility? Are Mixamo animation a good choice? They control all bones, and maybe custom animations on just specific bones could work better here, leaving the remaining bones free to be animated with a different animation or respond to physics.