αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10584-7 The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications for chemoresistant cancers.