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  "path": "/articles/s41586-026-10584-7",
  "publishedAt": "2026-05-28T06:09:22.115Z",
  "site": "https://www.nature.com",
  "tags": [
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  "textContent": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10584-7\n\nThe metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications for chemoresistant cancers.",
  "title": "αKG-mediated carnitine synthesis drives DNA repair via histone acetylation",
  "updatedAt": "2026-05-27T00:00:00.000Z"
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