Is Tramadol Safe? What the Latest Evidence Says

STORY AT-A-GLANCE Tramadol is widely prescribed for chronic pain because it’s perceived as “safer” than other opioids but more effective than other over-the-counter pain relievers, yet newer evidence challenges both its effectiveness and long-term safety A 2025 BMJ Evidence-Based Medicine analysis found tramadol reduced pain by less than one point on a 10-point scale, a […]