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  "path": "/t/randomized-non-comparative-trials-an-oxymoron/20863?page=5#post_85",
  "publishedAt": "2026-06-21T11:21:57.000Z",
  "site": "https://discourse.datamethods.org",
  "tags": [
    "@ESMD",
    "EHRs and RCTs: Outcome Prediction vs. Optimal Treatment Selection – Statistical Thinking"
  ],
  "textContent": "@ESMD I think your layout of the logic that is likely being used by proponents of RNCTs is excellent. At the core of their misunderstandings is mean squared error of treatment effect estimates. Even a small bias from historical controls will render their perceived variance reduction moot, as exemplified here - EHRs and RCTs: Outcome Prediction vs. Optimal Treatment Selection – Statistical Thinking.",
  "title": "Randomized non-comparative trials: an oxymoron?"
}