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  "path": "/t/a-longitudinal-renal-health-outcome-for-clinical-trials-in-acute-kidney-injury/28750#post_15",
  "publishedAt": "2026-05-21T23:27:12.000Z",
  "site": "https://discourse.datamethods.org",
  "tags": [
    "formulating sharply defined scientific theories",
    "PubMed",
    "Flawed design and selection bias in critical care randomized controlled..."
  ],
  "textContent": "davidcnorrismd:\n\n> This is, in my view, the very _opposite_ of a scientific question: it is a question rather about **how to industrialise the AKI research enterprise.** The core principle seems to be to deliver a generic outcome definition that liberates researchers from the burden of formulating sharply defined scientific theories specific to the particular intervention being ‘studied’.\n\nRespectfully I agree with David here. 2027 is the 40 year dark anniversary of the generation of non-disease specific ordinal scores (synthetic data generating processes) as outcomes for randomized trial use in critical care.\n\nThis popular article tells the sad story of how a pathological science based enterprise emerged in critical care to displace Fisher/Hill methodology. 30 such renal scores could be created each compared to mortality. You could add lactate, bili, hypotension, the list goes on. Then the scores could be compared to each other in terms of mortality or dialysis prediction. There is no limit to the study of synthetic data generating processes but reform is coming and these SDGP will be removed from the RCT tool chest.\n\nPubMed\n\n### Flawed design and selection bias in critical care randomized controlled...\n\nOver three decades, randomized controlled trials (RCTs) for critical care syndromes such as acute respiratory distress syndrome (ARDS), sepsis, and community acquired pneumonia (CAP) have repeatedly produced non-reproducible results, at times leading...",
  "title": "A Longitudinal Renal Health Outcome for Clinical Trials in Acute Kidney Injury?"
}