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  "path": "/t/a-longitudinal-renal-health-outcome-for-clinical-trials-in-acute-kidney-injury/28750#post_10",
  "publishedAt": "2026-05-19T23:13:48.000Z",
  "site": "https://discourse.datamethods.org",
  "tags": [
    "Zenodo",
    "A new structural analysis of randomized trials: three estimands for trial..."
  ],
  "textContent": "IMHO you should be commended for the hard work to create this consensus scoring system and this scoring system might be very useful for general broad indication of the severity of renal dysfunction across a ICU population. However this is a synthetic data generating process (SDGP) so it not useful in trials. I would recommend that the team try to find just one of the many hundreds of (perhaps a thousand) trials in the past where equivalent SDGP of SIRS or SOFA were useful in trials. Essentially all such trials failed or were reversed (sometimes for harm) for structural reasons. I haven’t examined the AKI literature but since it is also a SDGP, I suspect it has failed as well.\n\nThe result of the study of an SDGP is discussed here in this preprint which is in review.\n\nZenodo\n\n### A new structural analysis of randomized trials: three estimands for trial...\n\nThis article presents a new conceptual and methodological analysis of the transportability of randomized trial estimates under different enrollment structures. Building on prior structural work contrasting cause agnostic randomized controlled trials...",
  "title": "A Longitudinal Renal Health Outcome for Clinical Trials in Acute Kidney Injury?"
}