Dichotomization

Maybe some progress (?)

Turkiewicz A et al. Why Most Responder Analyses are Misleading. Osteoarthritis and Cartilage; 34(5), May 2026: 716-720.

https://www.sciencedirect.com/science/article/pii/S106345842501283X

“Importantly, it is not the existence of pre-specified thresholds for clinical relevance, such as minimally important difference, that is the problem, even though categorising continuous scales is almost always a bad idea[16]. The problem arises when this threshold is applied to individual observed change from baseline, because observed change from baseline is a suboptimal representation of a person’s response to treatment when dealing with outcomes that naturally fluctuate…”