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Sample size determination-confirmatory prognostic factor study

Datamethods Discussion Forum [Unofficial] April 24, 2026
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Covariate adjustment, as long as the covariates have some impact on Y, always increases power. For nonlinear model it seems to decrease power but this is a mirage. The standard errors can increase with covariate adjustment in say logistic or Cox models, but the \hat{\beta} increase more than that.

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