Sample size determination-confirmatory prognostic factor study
Datamethods Discussion Forum [Unofficial]
April 24, 2026
Covariate adjustment, as long as the covariates have some impact on Y, always increases power. For nonlinear model it seems to decrease power but this is a mirage. The standard errors can increase with covariate adjustment in say logistic or Cox models, but the \hat{\beta} increase more than that.
Discussion in the ATmosphere