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  "path": "/t/bayesian-randomized-non-inferiority-trial-design/28693#post_2",
  "publishedAt": "2026-04-04T13:23:22.000Z",
  "site": "https://discourse.datamethods.org",
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  "textContent": "A few random comments. Joint data analysis is in my view better than summarizing previous studies through priors. For one thing you can do covariate adjustment. See this which is not a meta-analysis, in the sense that it does not assume the data sources are exchangeable.\n\nBayes doesn’t need non-inferiority designs but rather just computes for example P(HR < 1.1).\n\nThe margin that is chosen is critical. It must be the same margin one would claim superiority with.",
  "title": "Bayesian randomized non-inferiority trial design"
}