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  "path": "/t/estimand-when-treatment-delays-disease-onset/28654#post_2",
  "publishedAt": "2026-03-04T20:38:44.000Z",
  "site": "https://discourse.datamethods.org",
  "textContent": "I maybe misunderstanding estimands, but why would you change your estimand given the result? For Clostridium (I refuse to change the name) difficile colitis, physicians use a vancomycin taper in the hope of preventing recurrence. There is no evidence that the taper did so. I would both as a physician and potential patient consider this a failure. If anything, the taper has caused harm because it delays the offering of another hopefully more effective treatment.",
  "title": "Estimand when treatment delays disease onset"
}