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  "path": "/t/estimand-when-treatment-delays-disease-onset/28654#post_5",
  "publishedAt": "2026-03-05T13:08:03.000Z",
  "site": "https://discourse.datamethods.org",
  "textContent": "I think the estimates framework is dramatically overhyped but still offers a bit. Particular judgments are key; the same as saying that a utility function needs to be considered before revealing the results. For a weight loss study the clear estimand would be the final weight, ignoring the journey. For a pain study, any day pain-free is good so using a Markov longitudinal model to estimate pain-free days or days with pain level < 2 would be appropriate. I’m not as clear on the clinical setting for the vanc study.",
  "title": "Estimand when treatment delays disease onset"
}