{
  "$type": "site.standard.document",
  "bskyPostRef": {
    "cid": "bafyreia6mpwrhex5zzuedaklxawdfja2cknoc5lioyowf25awt7muo7wni",
    "uri": "at://did:plc:wwyqal4cnqhuwyacdj7rqq3n/app.bsky.feed.post/3mgj45p7host2"
  },
  "path": "/t/estimand-when-treatment-delays-disease-onset/28654#post_1",
  "publishedAt": "2026-03-04T13:58:22.000Z",
  "site": "https://discourse.datamethods.org",
  "tags": [
    "interesting trial",
    "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825081"
  ],
  "textContent": "An interesting trial found that a treatment delayed disease onset, but did not reduce overall incidence at end of follow up:\n\n\n\nWhat estimand would you target in such cases?\n\nI thought about “difference in time unwell” as in https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825081 but I wonder if there are other interesting estimands for this interesting clinical case scenario",
  "title": "Estimand when treatment delays disease onset"
}