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  "path": "/t/lynn-s-paradox-of-sequential-rcts/28655#post_1",
  "publishedAt": "2026-03-05T23:09:19.000Z",
  "site": "https://discourse.datamethods.org",
  "textContent": "**Lynn’s Paradox** (with deference to Simpson)\n\n“A phenomenon in which sequential cause-agnostic randomized trials (CARs) testing a treatment for a disease-agnostic syndrome yield opposing conclusions across studies because enrolled participants represent a shifting mixture of diseases with opposing treatment effects.”",
  "title": "Lynn’s Paradox of Sequential RCTs"
}