Statin-related side effects: the recent Lancet publication is biased toward false-negatives
Datamethods Discussion Forum [Unofficial]
February 11, 2026
Even though I hate null hypothesis significance testing, I don’t believe that the statistical methods used for analysis of AEs are the explanation for not finding safety concerns, and find @ESMD most convincing. A better Bayesian analysis would convince even more, e.g. for lots of AEs compute P(absolute risk increase > 0.01 or odds ratio > 1.15) scrapping p-values which can detect trivial risk increases.
@ESMD I wonder if you agree with me that reporting counts of AEs in labels shares some of the fault. I’ve always thought that absolute risks should be emphasized much more.
Discussion in the ATmosphere