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Biomarker evaluation - c-statistic (AUC) and alternatives

Datamethods Discussion Forum [Unofficial] February 12, 2026
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Published yesterday in Circulation: https://doi.org/10.1161/CIR.0000000000001401 It’s an AHA Scientific Statement: “Criteria to Assess the Predictive and Clinical Utility of Novel Models, Biomarkers, and Tools for Risk of Cardiovascular Disease: A Scientific Statement From the American Heart Association”

I am wondering, why the “changes in the C-statistic” is again highlighted as well as “Categorical NRI […] at event rate […]” and in the whole statement there is not even one sentence about Likelihood ratio importance??

Discussion in the ATmosphere

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