Analysis of treatment switching using observational data

Is there a way to make any inference on the impact of treatment on a continuous variable using a non randomized group of subjects that switch on and off treatment? Can a simple comparison of the impact while on and off treatment determine if the treatment itself is impacting the outcome? switchdirectionality.pdf (4.8 KB) Clin Pharma and Therapeutics - 2025 - Collet - Statistical Methods to Adjust for Treatment Switching in Real‐World Clinical.pdf (653.0 KB)