{
  "$type": "site.standard.document",
  "path": "/t/analysis-of-treatment-switching-using-observational-data/28625#post_2",
  "publishedAt": "2026-01-30T17:23:04.000Z",
  "site": "https://discourse.datamethods.org",
  "textContent": "You are essentially asking if you can get the inference that a randomized crossover study gives without randomization. I think the answer is no. An exception would be in the pharmacokinetics setting where response are rapid and one can get causal inference by temporal alignment.",
  "title": "Analysis of treatment switching using observational data"
}