Parkinson's patients undergoing deep brain stimulation show little to no cortical Lewy pathology

Researchers at the Icahn School of Medicine at Mount Sinai have found that patients with Parkinson's disease undergoing deep brain stimulation (DBS) show little to no Lewy pathology in the prefrontal cortex at the time of their DBS surgery, despite often having longstanding, clinically advanced disease. Published in npj Parkinson's Disease, the findings provide important new insight into the relationship between Parkinson's disease clinical symptoms and neuropathological progression.