Blocking IL1RAP may weaken pancreatic cancer defenses before surgery

Blocking IL1RAP, a receptor that sits at a key control point in inflammatory signaling, can disrupt the tumor-driven inflammatory network that helps pancreatic cancer resist treatment, according to new research. Led by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, the findings are now advancing toward a first-of-its-kind neoadjuvant clinical trial combining IL1RAP-targeted therapy with chemoimmunotherapy in patients with operable pancreatic cancer before surgery.