Large-scale genetic study uncovers new factors associated with a pregnancy-related liver disease

Intrahepatic cholestasis of pregnancy (ICP) affects approximately 0.2–2% of pregnant women and typically develops after 30 weeks of gestation. As the most common symptom is severe itching of the palms and the soles of the feet, the condition can often be identified during routine prenatal care. The diagnosis is confirmed by elevated liver enzyme levels and increased concentrations of bile acids in the blood. Although the condition usually resolves after delivery, it is associated with an increased risk of complications, including preterm birth and stillbirth.