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  "path": "/news/2026-06-key-protein-chemotherapy-resistance-colorectal.html",
  "publishedAt": "2026-06-09T21:40:01.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "One of the most widely used chemotherapeutic agents for colorectal cancer is 5-fluorouracil (5-FU), a cornerstone treatment that has improved outcomes for countless patients. However, repeated treatment often leads to drug resistance, allowing cancer cells to adapt and gradually evade the effects of therapy.",
  "title": "Key protein behind chemotherapy resistance in colorectal cancer identified"
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