CAR-T cells enhanced with navigation system to penetrate lymph nodes more efficiently

Chimeric antigen receptor T-cell therapy, or CAR-T, has transformed treatment for blood cancers. The immunotherapy involves reprogramming a patient's own immune cells to recognize and attack tumor cells. It offers many patients long-lasting remission and even a cure. Yet the approach still fails in many lymphomas—cancers that affect the lymphatic system—especially when cancer cells are located in lymph nodes.