PET imaging reveals synaptic loss in multiple sclerosis across preclinical and human studies

A new PET imaging approach that measures synaptic density in the spinal cord provides a quantitative way to assess the brain's functional wiring in patients with multiple sclerosis. With this personalized information, physicians can monitor disease progression and evaluate whether new treatments are working to protect or restore these critical connections. This research was presented at the Society of Nuclear Medicine and Molecular Imaging's 2026 Annual Meeting.