CASK protein drives lung cancer growth by blocking a key tumor-suppressor gene

In a study published in the Journal of Biomedical Science, researchers from National Taiwan University found that CASK helps promote the growth of non-small cell lung cancer (NSCLC) by regulating the EGFR–p21 signaling pathway. Reducing CASK levels slowed cell growth and blocked cell cycle progression in NSCLC cells. At the same time, p21 expression increased significantly after CASK depletion under both normal and serum-free culture conditions.