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  "path": "/news/2026-05-code-p53-fragility-genome-guardian.html",
  "publishedAt": "2026-05-20T09:20:13.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it is also one of the most frequently mutated and dysfunctional proteins in human tumors.",
  "title": "Cracking the code of p53 fragility: Why the genome guardian is prone to failure"
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