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  "path": "/news/2026-05-longevity-linked-apoe2-gene-variant.html",
  "publishedAt": "2026-05-17T15:00:01.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanced age and are partly protected against Alzheimer's disease, but scientists have struggled to explain why. A new study from the Buck Institute for Research on Aging, now published in Aging Cell, offers a mechanistic answer: APOE2 helps human neurons keep their DNA intact and resist becoming senescent, a damaged, dysfunctional state that accumulates with age and contributes to neurodegeneration.",
  "title": "Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging"
}