Distinct metabolic signature found in patients with heart failure with preserved ejection fraction

What exactly happens in the hearts of patients with heart failure with preserved ejection fraction (HFpEF)—and how can this knowledge be used to develop new therapies? A research team led by Dr. Gabriele Schiattarella from the Deutsches Herzzentrum der Charité and a guest researcher at the Max Delbrück Center now has an answer: The heart muscle of patients with HFpEF and obesity shows a very distinct metabolic pattern—a kind of "metabolic fingerprint." This fingerprint, the researchers found, is distinct from people with obesity but who do not have symptoms of cardiometabolic diseases. The study is published in Cardiovascular Research.