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  "path": "/news/2026-05-metabolic-cancer-dna-machinery-lethal.html",
  "publishedAt": "2026-05-04T09:20:03.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "Loss of an enzyme necessary for a process called lipoylation disrupts the way cancer cells copy their DNA, increasing their vulnerability to a class of anticancer drugs known as PARP inhibitors, a study led by UT Southwestern Medical Center researchers shows.",
  "title": "One missing metabolic step can turn cancer's DNA-copying machinery into a lethal weakness"
}