{
  "$type": "site.standard.document",
  "bskyPostRef": {
    "cid": "bafyreicsp3s3ad6iai53hehcumlwnuaote3qemq5fcjsjs437xz2vhtn3m",
    "uri": "at://did:plc:pmmp7irwts7faw56jdxk3idc/app.bsky.feed.post/3mko3ogssydo2"
  },
  "coverImage": {
    "$type": "blob",
    "ref": {
      "$link": "bafkreidy3ymn3usli2ffkv3buxj2c7fseqzhsj2r27fjqtkwhrr3cdcana"
    },
    "mimeType": "image/jpeg",
    "size": 1421937
  },
  "path": "/news/2026-04-natural-molecule-boosts-car-therapy.html",
  "publishedAt": "2026-04-29T17:40:01.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "CAR-T cell therapy works well in blood cancers, but many patients still become resistant. A key reason is the presence of CAR-T regulatory T cells (CAR-Tregs), which weaken immune responses. Therefore, selectively targeting CAR-Tregs while preserving CAR-T activity remains a major challenge. Now, a pharmaceutical research team has identified a natural compound, timosaponin AIII (TAIII), that selectively eliminates CAR-T regulatory T cells. The study is published in Nature Communications.",
  "title": "A natural molecule boosts CAR-T therapy and turns cold tumors hot"
}