Depression treatment is shifting, and this mushroom-derived compound is driving one of psychiatry's biggest new tests

Depression is a debilitating mental health disorder that is estimated to affect approximately 5% of people worldwide. It is characterized by persistent feelings of sadness and hopelessness, a lack of interest in everyday activities, sleep disturbances, and possible changes in appetite. There are now several treatments for depression, including medications such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), as well as cognitive behavioral therapy (CBT) and other psychotherapeutic approaches. While many people diagnosed with depression respond well to one or more of these treatments, some experience few or no benefits.