Robust flu protection may rely on B cells that are long-lived residents in the lungs

Deep in the lungs, resident memory B cells stand guard against influenza reinfection—but whether they remain there may depend on how strongly they are signaled through their own receptors. New research using an animal model of influenza infection provides fresh insight into how these cells form and persist, findings that could inform the design of vaccines aimed at strengthening immune defenses in the lungs.