New mouse model reveals why chronic muscle inflammation resists standard drugs

An international research team with the participation of researchers from the University Medical Center Göttingen (UMG), Germany, has developed a mouse model that offers new insights into the development of a rare but serious muscle disease. The researchers were able to demonstrate that the persistent inflammation in inclusion body myositis is linked to impaired cellular "garbage disposal"—an important clue for new treatment strategies. The findings have been published in the journal Brain.