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  "path": "/news/2026-04-scientists-uncover-previously-unknown-chromatin.html",
  "publishedAt": "2026-04-07T13:00:04.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "As many as 1 in 4 cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex, which controls access to DNA. A study led by St. Jude Children's Research Hospital recently identified the gene-regulatory protein PHIP as a critical vulnerability in cancers driven by broad SWI/SNF inactivation. The work revealed PHIP as a potential therapeutic target for cancers, including rhabdoid tumors in children, and other hard-to-treat malignancies. The results are published in Nature Communications.",
  "title": "Scientists uncover previously unknown chromatin regulation mechanism with therapeutic potential for pediatric cancer"
}