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  "path": "/news/2026-03-psilocybin-combined-psychotherapy-significant-efficacy.html",
  "publishedAt": "2026-03-19T12:40:05.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "There is an urgent need for new and more effective treatments for depression. The results of a recent study show that psilocybin, an active compound found in certain mushrooms, can have a significant antidepressant effect. For the treatment to be successful and safe, it is important that it be integrated into a psychotherapeutic program that includes both pre- and post-treatment support.",
  "title": "Psilocybin combined with psychotherapy shows significant efficacy in treatment-resistant depression"
}